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In such circumstances, nitrates should still only be administered under close medical supervision with appropriate hemodynamic monitoring [see Contraindications 4. Six randomized, double-blinded, crossover clinical pharmacology studies were conducted to investigate the potential interaction of tadalafil with alpha-blocker agents in healthy male subjects [see Dosage and Administration 2. In four studies, a single oral dose of tadalafil was administered to healthy male subjects taking daily at least 7 days duration an oral alpha-blocker. In two studies, a daily oral alpha-blocker at least 7 days duration was administered to healthy male subjects taking repeated daily doses of tadalafil. Doxazosin Three clinical pharmacology studies were conducted with tadalafil and doxazosin, an alpha[1]-adrenergic blocker. Doxazosin was administered at the same time as tadalafil or placebo after a minimum of seven days of doxazosin treatment for Erection Problem see Table 5 and Reasons of ED 2. Blood pressure was measured manually at 1, 2, 3, normal erection, 4, 5, 6, 7, 8, 10, 12, and 24 hours after tadalafil or placebo administration. There were nine and three outliers following administration of tadalafil 20 mg and placebo, respectively. Severe adverse events potentially related to blood-pressure effects were assessed. No such events were reported following placebo. Two such events were reported following administration of tadalafil. Vertigo was reported in one subject that began 7 hours after dosing and lasted about 5 days.

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Take this medication by mouth, with or without food, as directed by your doctor. Do not take tadalafil more often than once daily. The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. To treat the symptoms of BPH, take this medication as directed by your doctor, usually once a day. If you are also taking finasteride treatment for Erection Problem this medication to treat symptoms of BPH, talk with your doctor about how long you should continue taking this medication. To treat erectile dysfunction-ED, there are 2 ways that tadalafil may be prescribed. Your doctor will determine which is the best way for you to take tadalafil, Tadalafil. The first way is to take it as needed, usually at least 30 minutes before sexual activity. The second way to treat ED is to take tadalafil regularly, once a day every problems with erection. If you take it this way, you may attempt sexual activity at any time between your doses. If you are taking tadalafil to treat both ED and BPH, take it as directed by your doctor, usually once a day. You may attempt sexual activity at any time between your doses. If you are taking tadalafil once daily for BPH, or for ED, or for both, take it regularly to get the most benefit from it. To help you remember, take it at the same time each day.

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